Preoperative radiation therapy with fast neutrons for locally advanced breast cancer consists of 3 sessions with a 48-72 hour interval for 8-12 days, single radiation dose 2.4 Gy up to a total tumor dose 7.2 Gy (38-40 Gy photon therapy). Three to five sessions of neutron therapy at a total dose of 6.6 ± 1.5 Gy are given for the treatment of local recurrences. Two regimens of neutron therapy and mixed radiation therapy for malignant tumors of salivary and thyroid glands are suggested. Combination of IORT and DGT is given in 2 regimens: 1) IORT is followed by DGT; 2) preoperative DGT is followed by surgery with IORT. Regimens of neutron, intraoperative and mixed radiation therapy have been created on the base of radiobiological and mathematical models. The modified mathematical model TDF (time-dose-fractionation) is used.